Thermo Fisher Scientific PGLYRP1 Polyclonal Antibody
Thermo Fisher Scientific의 PGLYRP1 Polyclonal Antibody는 인간 단백질 PGLYRP1을 인식하는 고품질 토끼 IgG 항체입니다. Western blot에 적합하며, KLH 결합 합성 펩타이드로 면역화되었습니다. 연구용으로만 사용되며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다.
- 카탈로그번호
- PA5116295
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 147–174 amino acids from the C-terminal region of human PGLYRP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900929 |
Target Information
The primary immune recognition is based on structures common among invading pathogens.
Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever.
Recently, a family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that bind to peptidoglycans expressed on Gram-positive bacteria.
Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and is an excellent target for recognition by the eukaryotic innate immune system.
The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.
- PGRP-L is primarily expressed in the liver and contributes to host defense by producing acute phase proteins and clearing microorganisms from blood.
- PGRP-S is present in neutrophils, inhibits growth of Gram-positive bacteria, and may serve as a neutrophil antibacterial protein. It is also expressed in bone marrow at levels 50–100 times higher than in neutrophils, suggesting additional functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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