Thermo Fisher Scientific PGLYRP1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000

Product Specifications

Target Information

The primary immune recognition is based on structures common among invading pathogens.
Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever.

Recently, a family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that bind to peptidoglycans expressed on Gram-positive bacteria.
Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and is an excellent target for recognition by the eukaryotic innate immune system.

The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.

• PGRP-L is primarily expressed in the liver and contributes to host defense by producing acute phase proteins and clearing microorganisms from blood.
• PGRP-S is present in neutrophils, inhibits growth of Gram-positive bacteria, and may serve as a neutrophil antibacterial protein. It is also expressed in bone marrow at levels 50–100 times higher than in neutrophils, suggesting additional functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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