Thermo Fisher Scientific HTR1B Polyclonal Antibody

Applications

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, feline, mouse, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) is a serum factor involved in regulating diverse biological processes in the central and peripheral nervous systems, cardiovascular system, and gastrointestinal system.
Molecular cloning studies have identified five receptors belonging to the 5-HT1 subtypes, which are negatively coupled to adenylyl cyclase.
Radioligand binding studies indicate the presence of 5-HT1B (formerly 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior colliculus.
In situ hybridization studies reveal abundant 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus, and lower levels in caudate-putamen, cortical areas, thalamic, and hypothalamic nuclei.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.