ELK Biotechnology ANPRA rabbit pAb
ANPRA rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체입니다. WB 및 ELISA에 적합하며, 1 mg/ml 농도로 제공됩니다. -20°C에서 1년 보관 가능하며, 세포막 단일 통과형 단백질을 인식합니다.
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ANPRA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 116 kD |
| Gene ID (Human) | 4881 |
| Human Swiss-Prot No. | P16066 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]).
The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain.
GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961).
Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains.
NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides.
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