ELK Biotechnology P3C2B rabbit pAb
P3C2B 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에서 반응하며, 세포 내 다양한 부위에 발현된 단백질 검출에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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- pk
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제품명
P3C2B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 179 kD |
| Gene ID (Human) | 5287 |
| Human Swiss-Prot No. | O00750 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Microsome, Cell membrane, Cytoplasm (cytosol), Nucleus, Endoplasmic reticulum. Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. |
Background
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes and may also mediate protein-protein interactions.
The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, suggesting that this enzyme may function in a calcium-independent manner.
[provided by RefSeq, Jul 2008]
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