ELK Biotechnology PLCE1 rabbit pAb
PLCE1 단백질을 인식하는 토끼 다클론 항체로, IHC 및 IF에 사용 가능. 세포막 및 골지체 등 다양한 세포소기관에서 발현된 단백질 검출에 적합. 고순도 IgG 형태로 제공되며, -20°C에서 1년 보관 가능.
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제품명
PLCE1 rabbit pAb
제품 개요
PLCE1 단백질을 표적하는 토끼 다클론 항체입니다. 인체, 생쥐, 랫트 시료에서의 면역조직화학(IHC) 및 면역형광(IF) 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 253 kD |
| Gene ID (Human) | 51196 |
| Human Swiss-Prot No | Q9P212 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, cytosol, cell membrane, Golgi apparatus membrane, cell projection (lamellipodium). Recruited to plasma membrane by activated HRAS and RAP2, to perinuclear membrane by activated RAP1A. Isoform 1 and 2 associate with Golgi membranes. |
Background
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers regulate processes affecting cell growth, differentiation, and gene expression. The enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, it has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (RefSeq, Sep 2009)
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