ELK Biotechnology MRCKG rabbit pAb

ELK Biotechnology MRCKG rabbit pAb

제품 설명

MRCKG 단백질을 인식하는 토끼 폴리클로날 항체입니다. 세포질 내에서 주로 발현되며, 세포 이동 및 골격 재구성 관련 신호전달 경로 연구에 사용됩니다.

제품 정보

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Maintained in an inactive, closed conformation by interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this interaction, allowing N-terminus-mediated dimerization and kinase activation by transautophosphorylation.
• Function: Acts as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to actomyosin contractility required for cell invasion through regulation of MYPT1 and MLC2 phosphorylation.
• Similarity: Belongs to the protein kinase superfamily (AGC Ser/Thr protein kinase family, DMPK subfamily). Contains AGC-kinase C-terminal, CNH, CRIB, PH domains, phorbol-ester/DAG-type zinc finger, and protein kinase domain.
• Subcellular location: Concentrates at the leading edge of cells.
• Subunit: Forms homodimer and homotetramer via coiled-coil regions; interacts tightly with GTP-bound CDC42.
• Tissue specificity: Expressed in heart and skeletal muscle.