ELK Biotechnology CDC42 rabbit pAb

제품명

CDC42 rabbit pAb

적용 분야

• WB (Western Blot)
• ELISA

권장 희석 배수

• WB: 1:500–1:2000
• ELISA: 1:5000–1:20000

스펙 정보

세포 내 위치

Cell membrane; Lipid-anchor; Cytoplasmic side.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cytoplasm, cytoskeleton, spindle, midbody, dendrite.
Localizes to spindle during prometaphase cells and moves to the central spindle as cells progress through anaphase to telophase (PubMed:15642749).
Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749).
Localization regulated by guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749).
Colocalizes with NEK6 in the centrosome (PubMed:20873783).
In its active GTP-bound form, localizes to the leading edge membrane of migrating dendritic cells (By similarity).

배경 정보

The protein encoded by this gene is a small GTPase of the Rho-subfamily, regulating signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis, and cell cycle progression.
It is highly similar to Saccharomyces cerevisiae Cdc42 and can complement the yeast cdc42-1 mutant.
The product of oncogene Dbl catalyzes GDP dissociation from this protein.
CDC42 regulates actin polymerization through direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), activating the Arp2/3 complex.
Alternative splicing results in multiple transcript variants.
Pseudogenes are identified on chromosomes 3, 4, 5, 7, 8, and 20. [RefSeq, Apr 2013]

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