ELK Biotechnology VATB2 rabbit pAb
V-ATPase 복합체 구성요소 VATB2를 인식하는 토끼 폴리클로날 항체입니다. WB 및 ELISA에 적합하며, 인간, 랫드, 마우스, 돼지 시료에 반응합니다. 고순도 IgG 형태로 제공되며, -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology VATB2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | VATB2 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| GeneID (Human) | 526 |
| Human Swiss-Prot No | P21281 |
| Species Reactivity | Human; Rat; Mouse; Swine |
| Cellular Localization | Apical cell membrane, melanosome, cytoplasm, cytoplasmic vesicle (secretory and synaptic vesicle membrane); peripheral membrane protein; identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme mediating acidification of eukaryotic intracellular organelles. V-ATPase-dependent organelle acidification is essential for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
V-ATPase consists of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain contains three A, three B, and two G subunits, as well as C, D, E, F, and H subunits, and includes the ATP catalytic site. The encoded protein represents one of two V1 domain B subunit isoforms, being the only B isoform highly expressed in osteoclasts.
[provided by RefSeq, Jul 2008]
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