Thermo Fisher Scientific TACR3 Polyclonal Antibody
TACR3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TACR3 (Accession P29371), corresponding to amino acid residues Y401–S451 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851535 |
Product Specific Information
Antibody detects endogenous levels of total NK3R.
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B. These peptides act on three related but distinct seven-transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has the greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin into circulation.
NK3R may be involved in learning and memory, as mice lacking this gene exhibit cognitive deficits. It may also play a role in regulating vagal afferent relay neurons, though these receptors are likely activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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