Thermo Fisher Scientific AKR1B10 Polyclonal Antibody
Human AKR1B10 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 감도를 제공. HeLa 및 HCT116 양성 대조군 권장. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 120–316 of Human AKR1B10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2548247 |
Product Specific Information
- Recommended positive controls: HeLa, HCT116
- Predicted reactivity: Mouse (85%), Rat (84%), Rabbit (91%), Bovine (80%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
AKR1B10 is a 316 amino acid protein that catalyzes efficient reduction of aliphatic and aromatic aldehydes. It is the first cytosolic NADP(H)-dependent retinal reductase described in humans and features a novel NADP binding motif. AKR1B10 may play a role in secondary diabetic complications through its ability to convert glucose to sorbitol. It is abundantly expressed in adrenal gland, small intestine, and colon, with lower expression in liver, thymus, prostate, testis, and skeletal muscle. Expression levels are upregulated in certain cancers such as hepatocellular carcinoma.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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