Thermo Fisher Scientific CaMKII gamma Polyclonal Antibody
CaMKII gamma 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB 및 ICC/IF에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CaMKII gamma. Recombinant protein control fragment (Product #RP-104723) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663253 |
Product Specific Information
Immunogen sequence:
NSLVSPAQEPA PLQTAMEPQT TVVHNATDGI KGSTESCNTT TEDEDLKAAP LRTGNGSSVP EGRSSR
Highest antigen sequence identity to the following orthologs:
- Mouse: 72%
- Rat: 97%
Target Information
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation. Involved in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle.
In neurons, it plays an essential structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner. This function is required for correct targeting of CaMK2A, promoting dendritic spine and synapse formation and maintaining synaptic plasticity enabling long-term potentiation (LTP) and hippocampus-dependent learning.
In developing hippocampal neurons, it promotes dendritic arborization, and in mature neurons, dendritic remodeling. It also modulates skeletal muscle function in response to exercise, regulating SR Ca(2+) transport in slow-twitch muscle and controlling Ca(2+) release in fast-twitch muscle via phosphorylation of triadin and phospholamban.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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