Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody
Thermo Fisher Scientific의 alpha-1 Antitrypsin Polyclonal Antibody는 인간 단백질에 반응하는 고품질 Rabbit IgG 항체입니다. Western blot 및 IHC에 사용 가능하며, 2 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용되며, 장기 보관 시 -20°C에서 보관 권장됩니다.
- 카탈로그번호
- PA526439
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publication: 1 available
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Not specified
- Publication: 1 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 158–187 amino acids from the central region of human SERPINA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion - Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543939 |
Target Information
Alpha-1-AT is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and can digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress of the newborn.
Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum levels of alpha-1-AT are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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