ELK Biotechnology Alix rabbit pAb
Alix rabbit pAb는 인간, 생쥐, 랫트에서 반응하는 다클론 항체로, 세포질 및 세포골격 관련 단백질 Alix를 검출합니다. WB 및 ELISA에 적합하며, ESCRT 경로 관련 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology Alix rabbit pAb
제품 개요
Alix rabbit pAb는 인간 Alix 단백질을 인식하는 고품질 다클론 항체로, 세포 분열 및 세포사 과정에 관련된 단백질 연구에 사용됩니다. ESCRT 경로, 세포질 및 세포골격 관련 연구에 적합합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | Alix rabbit pAb |
| Alternative Names | Programmed cell death 6-interacting protein (PDCD6-interacting protein; ALG-2-interacting protein 1; Hp95) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA(peptide) 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human Alix (AA range: 410–490) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85–100 kD |
| GeneID (Human) | 10015 |
| Human Swiss-Prot No | Q8WUM4 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Cytoplasm, cytosol, melanosome, cytoskeleton, microtubule organizing center, centrosome, extracellular exosome, cell junction (tight junction), midbody, midbody ring.
Identified by mass spectrometry in melanosome fractions from stage I to IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires interaction with CEP55 (PubMed:18641129).
배경 정보
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the PDCD6 gene product in a calcium-dependent manner. It also interacts with endophilins, which regulate membrane shape during endocytosis. Overexpression of Alix and endophilins results in cytoplasmic vacuolization, possibly contributing to protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been identified, and related pseudogenes exist on chromosome 15. (RefSeq, Jan 2012)
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