ELK Biotechnology APEX2 rabbit pAb
Human APEX2 단백질을 인식하는 rabbit polyclonal antibody로 WB에 적합. 핵, 세포질, 미토콘드리아에서의 APEX2 단백질 검출에 사용. -20°C에서 1년 보관 가능하며 IgG 아이소타입. 인간 및 생쥐 시료에 반응.
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제품명
APEX2 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
APEX2 rabbit polyclonal antibody는 인간 APEX2 단백질을 인식하며, Western Blot(WB) 분석에 적합합니다. 해당 단백질은 DNA 손상 복구 과정에서 핵과 미토콘드리아에 존재하는 것으로 알려져 있습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human APEX2 (AA 196–246) |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 27301 |
| Human Swiss-Prot No | Q9UBZ4 |
| Cellular Localization | Nucleus, Cytoplasm, Mitochondrion. Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. |
| Species Reactivity | Human, Mouse |
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, DNA damaging agents, or DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication, so cells contain systems to identify and repair such sites.
Class II AP endonucleases cleave the phosphodiester backbone 5′ to the AP site.
This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
[Provided by RefSeq, Nov 2012]
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