Thermo Fisher Scientific JAK2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human JAK2 protein. Suitable for IHC and IHC (Paraffin) applications. Purified by antigen affinity chromatography and supplied as liquid form at 0.25 mg/mL. Stored at 4°C with 1-year shelf life. For research use only.
- 카탈로그번호
- IHC00631x (2개 옵션)
- 판매단위
- pk
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1082 and 1132 of human Janus kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Predicted to react with Dog, Horse, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Naked mole rat, and Ferret (based on 100% sequence identity)
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated genes. JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Mutations in JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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