Thermo Fisher Scientific CD3e (T-Cell Marker) Recombinant Rabbit Monoclonal Antibody (C3e/8116R)

Applications and Tested Dilution

Product Specifications

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the surface expression of the TCR complex. T cell activation through the TCR involves the cytoplasmic tails of the CD3 subunits (CD3γ, CD3δ, CD3ε, and CD3ζ). These subunits are structurally related members of the immunoglobulin superfamily encoded by genes on human chromosome 11.
CD3 subunits associate with cytoplasmic signal transduction molecules through a double tyrosine-based motif. CD3 plays a role in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding CD3 epsilon, gamma, and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.