Thermo Fisher Scientific ATOH1 Monoclonal Antibody (4D10)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK

Target Information

The Drosophila atonal gene produces a protein with basic helix-loop-helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system.
Mammalian atonal homolog 1 (MATH-1), also known as Atoh1, Ath1, or HATH-1, is a helix-loop-helix (HLH) transcription factor structurally homologous to the product of the Drosophila proneural gene atonal.
MATH-1 is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression occurs by embryonic day 9.5, initially localizing to the cranial ganglia and dorsal part of the central nervous system.
Expression becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system.
It is suggested that MATH-1 may play a role in differentiation of subsets of neural cells by activating E box-dependent transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.