Thermo Fisher Scientific GPR68 (OGR1) (extracellular) Polyclonal Antibody, FITC

Applications

• Flow Cytometry (Flow): Tested dilution 2.5 µg

Product Specifications

Product Specific Information

Reconstitution: Add 15 µL or 50 µL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

GPR68 (also known as OGR1, ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It acts as an osteoblastic pH sensor regulating cellular responses to acidosis in bone.
GPR68 mediates its effects through G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization.
The receptor is nearly silent at pH 7.8 but fully activated at pH 6.8. It may serve as a tumor suppressor in prostate cancer.
Mutations in this gene cause amelogenesis imperfecta, hypomaturation type 2A6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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