Thermo Fisher Scientific MAF Monoclonal Antibody (OTI8F4), TrueMAB
MAF 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI8F4). Western blot에 적합하며, Human 시료에 반응. Affinity chromatography로 정제된 액상 제품으로, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8F4 |
| Immunogen | Full length human recombinant protein of human MAF produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
c-MAF is the cellular counterpart of oncogenic v-maf and belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain mediates interaction with LRPICD. Two forms of human c-maf mRNA exist: c-maf-long and c-maf-short. It was identified in the genome of the acute transforming avian retrovirus AS42.
c-maf targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, where it binds to the Maf recognition element (MARE) to regulate transcription. It plays a role in Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberrations involving maf are associated with some forms of multiple myeloma. Expression is found in myeloma cell lines and resting monocytes/macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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