Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Qdot 800

Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Qdot 800

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: Assay-dependent
  • View 3 publications

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 405
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• TRI-COLOR
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays a crucial role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules. It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers of CD8α. Engagement of MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key to pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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