Thermo Fisher Scientific SGOL1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAKERCLKKS FQDSLEDIKK RMKEKRNKNL AEIGKRRSFI AAPCQIITNT STLLKNYQDN NKMLVLALEN EKSKVKEAQD IILQLRKECY YLTCQLYALK GKLTSQQTVE PAQNQEICSS GMDPNSDDSS RNLFVKDLPQ IPLEETELPG QGESFQIEAT PPETQQSPHL SLKDITNVSL YPVVKIRRLS LSPKKNKASP AVALPKRRCT ASVNYKEPTL ASKLRRGDPF TDLCFLNSPI FKQKKDLRRS KKRALEVSPA KEAIFILYYV REFVSRFPDC RKCKLETHIC LR

Target Information

The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. This protein may also protect cohesin along chromosome arms.
An isoform lacking exon 6 plays a role in centriole cohesion. Mutations in this gene are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO). Fibroblast cells from CAID patients show increased proliferation and senescence. Pseudogenes of this gene are found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.