Thermo Fisher Scientific CHD8 Recombinant Rabbit Monoclonal Antibody (20H56L8)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:100

-

ChIP assay (ChIP)

2.5 µg/million cells

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

20H56L8

Immunogen

Protein corresponding to human CHD8 [aa2291-aa2364] if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CHD8,uniProtId:Q9HCK8-1,ncbiNodeId:9606,antigenRange:2291-2364,antigenLength:2581,antigenImageFileName:703595_CHD8_Q9HCK8-1_Rabbit.svg,antigenImageFileNamePDP:703595_CHD8_Q9HCK8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2848232

Product Specific Information

This antibody is predicted to react with Mouse, Rat, Bovine

Target Information

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.