Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI 3D8)
ITFG2 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 Flow cytometry에 적합. 인간 시료 반응성, 비결합형 액상 형태, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI 3D8 |
| Immunogen | Full length human recombinant protein of ITFG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3), with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724530 |
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway.
It recruits the GATOR1 complex to lysosomal membranes, enabling its interaction with GATOR2 and the RAG GTPases.
Functions upstream of the RAG GTPases and negatively regulates mTORC1 signaling in absence of amino acids.
Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated.
The KICSTOR complex is also likely involved in mTORC1 regulation by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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