Thermo Fisher Scientific HCAR2 Polyclonal Antibody
Human HCAR2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HCAR2. Recombinant protein control fragment (Product #RP-88978) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642327 |
Product Specific Information
- Immunogen sequence:
NRCLQRKMTG EPDNNRSTSV ELTGDPNKTR GAPEALMANS GEPWSPSYLG P - Highest antigen sequence identity to orthologs:
Mouse - 69%, Rat - 67%
Target Information
GPR109A (also known as HCA2, HM74a, and NIACR1) is a 42 kDa G-protein coupled receptor belonging to the hydroxyl-carboxylic acid receptor family, which includes GPR109B and GPR81.
GPR109A has two known ligands: niacin and butyrate (or 3-hydroxybutyrate).
GPR109A is expressed on adipocytes, neutrophils, Langerhans cells, keratinocytes, intestinal epithelial cells, and colonic macrophages.
Niacin (vitamin B3) improves cholesterol metabolism (LDL/HDL ratio) and reduces inflammation via GPR109A activation.
GPR109A also plays a critical role in suppressing inflammation and colon cancer.
In mice, GPR109A expression in intestinal epithelial cells and macrophages contributes to colitis and cancer suppression.
In humans, GPR109A is silenced in colon carcinoma cells by DNA methylation, increasing intestinal inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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