Thermo Fisher Scientific CDKN2A (p16INK4a) Monoclonal Antibody (OTI4C11), TrueMAB
CDKN2A (p16INK4a) 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC/IF에 사용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. 세포주기 조절 및 종양 억제 단백질 연구용에 적합.
- 카탈로그번호
- TA500036x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CDKN2A (p16INK4a) Monoclonal Antibody (OTI4C11), TrueMAB
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Miscellaneous PubMed (Misc) | - | View 4 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase.
The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein structurally unrelated to the other variants.
The ARF product functions as a stabilizer of the tumor suppressor protein p53 by interacting with and sequestering the E3 ubiquitin-protein ligase MDM2, responsible for p53 degradation.
Despite structural and functional differences, CDK inhibitor isoforms and the ARF product share a common role in cell cycle G1 control through CDK4 and p53 regulation.
This gene is frequently mutated or deleted in many tumors and is an important tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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