Thermo Fisher Scientific PHKB Polyclonal Antibody
PHKB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도, PBS와 50% 글리세롤 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PA599686
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PHKB (Accession Q93100), corresponding to amino acid residues V206–G256 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818619 |
Product Specific Information
Antibody detects endogenous levels of total PHKB.
Target Information
Phosphorylase kinase is a hexadecameric enzyme composed of four copies of four subunits encoded by PHKA, PHKB, PHKG, and PHKD genes. This serine/threonine-specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, releasing glucose-1-phosphate from glycogen.
PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093-amino-acid subunit of phosphorylase kinase that, along with PHKA, has regulatory functions controlled by phosphorylation. Defects in the PHKB gene cause glycogen storage disease type 9B (phosphorylase kinase deficiency of liver and muscle), characterized by mild hepatomegaly, slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and gradual improvement with age. Four isoforms of PHKB are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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