Thermo Fisher Scientific uPAR Monoclonal Antibody (R-4)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MONR402 | - | Thermo Fisher Scientific MONR402 uPAR Monoclonal Antibody (R-4) 200 ul pk | 재고문의 | pk | 0원 | - | 0원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
Assay-dependent
View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))
Assay-dependent
Immunohistochemistry (Frozen) (IHC (F))
Assay-dependent
Flow Cytometry (Flow)
Assay-dependent
ELISA (ELISA)
Assay-dependent
Product Specifications
Published species
Human
Host/Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
R-4
Immunogen
Native human uPAR.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1.09 mg/mL
Storage conditions
4° C, store in dark
Shipping conditions
Wet ice
RRID
AB_2539793
Product Specific Information
Specificity: MON R-4-02 does not cross-react with mouse uPAR, human uPA, human tPA or human PAI-1 when tested by ELISA and immunoblotting.
Reactivity: MON R-4-02 reacts with domain 3 in immunoprecipitation using proteolytic fragments of recombinant suPAR. This antibody is suitable for Western blotting of non-reduced proteins and can be used as a detection antibody in ELISA applications.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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