Thermo Fisher Scientific LCLAT1 Polyclonal Antibody
Human LCLAT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P) 적용 가능, 항원 친화 크로마토그래피로 정제. PBS/glycerol buffer로 안정화되어 장기 보관에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LCLAT1. Recombinant protein control fragment (Product #RP-95707). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643308 |
Product Specific Information
- Immunogen sequence:
ICLKASLKGV PGFGWAMQAA AYIFIHRKWK DDKSHFEDMI DYFCDIHEPL QLLIFPEGTD LTENSKSRSN AFAEKNGLQK YEYV - Highest antigen sequence identity to orthologs:
Mouse – 90%, Rat – 89%
Target Information
LCLAT1 exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity, catalyzing the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling. It recognizes both monolysocardiolipin and dilysocardiolipin as substrates, with preference for linoleoyl-CoA and oleoyl-CoA as acyl donors.
Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT) activity, converting lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating an acyl moiety at the sn-2 position.
Possesses lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities.
Required for establishment of hematopoietic and endothelial lineages.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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