Thermo Fisher Scientific ABL1/ABL2 Polyclonal Antibody
ABL1/ABL2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합. Human, Mouse, Non-human primate 시료 반응. Affinity chromatography로 정제, PBS+50% glycerol에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABL1 (Accession P00519), corresponding to amino acid residues R367–S417 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899441 |
Product Specific Information
This antibody detects endogenous levels of total ABL1/2.
Target Information
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including:
- 90–95% of chronic myelocytic leukemia (CML)
- 20–25% of adult acute lymphoblastic leukemia (ALL)
- 2–5% of pediatric ALL
In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. This results in the generation of a chimeric Bcr/c-Abl mRNA encoding an activated Abl protein-tyrosine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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