Thermo Fisher Scientific DNER Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: Hela, HT-29, Mouse brain, Mouse eye, Mouse small intestine, Rat brain.
The target is typically localized to the cell membrane as a single-pass type I membrane protein.

Immunogen sequence:
PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W

Target Information

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and neuronal cell bodies throughout the central nervous system.
It contains ten extracellular EGF-like domains homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells and mediates neuron-glia interaction during astrocytogenesis through direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts.
This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and regulates their morphogenesis. DNER is essential for the functional and morphological maturation of Bergmann glia. DNER-knockout mice exhibit motor discoordination and cerebellar developmental retardation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.