Thermo Fisher Scientific HLA-B27 Polyclonal Antibody
Rabbit에서 유래한 HLA-B27 폴리클로날 항체로, Western blot, IHC(P), IP에 적합합니다. 합성 펩타이드를 면역원으로 사용하며 비결합형 액상 형태입니다. 연구용으로만 사용 가능하며, -20°C에서 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 0.5–2 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human HLA-B27 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2902592 |
Target Information
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is membrane-anchored and plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. These molecules are expressed in nearly all cells.
The heavy chain (~45 kDa) gene contains 8 exons:
- Exon 1: Leader peptide
- Exons 2–3: Alpha1 and Alpha2 domains (peptide binding)
- Exon 4: Alpha3 domain
- Exon 5: Transmembrane region
- Exons 6–7: Cytoplasmic tail
Polymorphisms within exons 2 and 3 determine the peptide-binding specificity of each class I molecule. Typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation. Numerous HLA-A alleles have been described.
HLA and MHC antibodies are important in Immunopeptidomics, aiding in the identification and characterization of neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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