Thermo Fisher Scientific FNIP2 Polyclonal Antibody
Western blot, IHC, IP 등 다양한 응용에 적합한 FNIP2 폴리클로날 항체. Rabbit IgG 유래로 높은 특이성과 재현성을 제공. 항원 친화 크로마토그래피로 정제되어 신뢰성 높은 결과 보장. Human 시료 반응성, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human FNIP2 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902560 |
Target Information
FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin acts as a tumor suppressor, as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein sharing 49% identity with FNIP2, bind to AMPK, an important energy sensor that negatively regulates the mammalian target of rapamycin (mTOR), a key regulator of cell growth and proliferation. FNIP1 and FNIP2 can form homo- and heteromeric multimers, suggesting a functional relationship between these proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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