Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI26F7), TrueMAB

Applications

• Flow Cytometry (Flow): Tested dilution 1:50

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes activated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which mediate suppression signals upon binding to ligands PDL-1 or PDL-2.
PD-1 signaling inhibits immune activation in the absence of danger signals (e.g., LPS). PD-1 deficient mice exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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