Thermo Fisher Scientific RIG-I Polyclonal Antibody
Thermo Fisher Scientific의 RIG-I Polyclonal Antibody는 인간 RIG-I 단백질을 인식하는 토끼 IgG 항체로, WB, IHC, ELISA에 적합합니다. 합성 펩타이드를 면역원으로 사용하며, 고순도 친화 크로마토그래피로 정제되어 안정적인 신호 검출을 제공합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:4,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 825–925 of human Rig-I/DDX58 (NP_055129.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.47 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855708 |
Product Specific Information
Immunogen sequence:
VIEECHYTVL GDAFKECFVS RPHPKPKQFS SFEKRAKIFC ARQNCSHDWG IHVKYKTFEI PVIKIESFVV EDIATGVQTL YSKWKDFHFE KIPFDPAEMS K
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases performing overlapping and distinct roles.
RIG-I is activated by dsRNAs without a 5'-triphosphate end and short dsRNAs, whereas MDA5 responds to long dsRNAs. Once activated, both signal through IPS-1, activating transcription factors NF-κB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A/B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I targets (TRAF6, IRAK1, IRAK2), providing feedback inhibition.
Recent evidence suggests RIG-I also detects cytosolic DNA via RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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