Thermo Fisher Scientific Cyclin B1 (G2- and M-phase Cyclin) Recombinant Rabbit Monoclonal Antibody (CCNB1/7030R)
Cyclin B1 단백질을 인식하는 재조합 토끼 단클론 항체로, G2/M 세포주기 전환 연구에 적합. 인간, 생쥐, 햄스터 반응성. HEK293 발현 시스템 사용, Protein A/G 정제, 액상 형태로 제공. 연구용 전용 제품.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CCNB1/7030R |
| Immunogen | Recombinant full-length human CCNB1 protein (Cyclin B1, UniProt ID: P14635-1, Antigen Range: 1–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cyclins bind to and regulate the activity of Cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and is essential for controlling the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF).
Two alternative transcripts exist: one constitutively expressed and another cell cycle-regulated, predominantly during G2/M phase. Cyclin B1 accumulation during G2 phase and its APC-dependent destruction at the end of mitosis are crucial for cell cycle progression.
Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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