Thermo Fisher Scientific CASP3 Monoclonal Antibody (4D3)
인간 CASP3 단백질을 인식하는 마우스 단클론 항체로 ELISA 및 in situ PLA에 사용 가능. GST 태그가 결합된 재조합 단백질을 면역원으로 제작. PBS 완충액에 보존되며 방부제 무첨가. -20°C에서 보관하며 반복 동결/해동은 피해야 함.
- 카탈로그번호
- H00000836-M02
- 판매단위
- pk
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Thermo Fisher Scientific CASP3 Monoclonal Antibody (4D3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 1 ng/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D3 |
| Immunogen | CASP3 (AAH16926.1, 176 a.a. approximately 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SGVDDDMACH KIPVEADFLY AYSTAPGYYS WRNSKDGSWF IQSLCAMLKQ YADKLEFMHI LTRVNRKVAT EFESFSFDAT FHAKKQIPCI VSMLTKELYF YH
Target Information
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.
This protein cleaves and activates caspases 6, 7, and 9, and the protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer’s disease.
Alternative splicing of this gene results in two transcript variants that encode the same protein.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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