Thermo Fisher Scientific JMJD3 Polyclonal Antibody
JMJD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 반응성, 고순도 정제, 액상 형태로 제공되며 연구용으로 적합. 장기 보관 시 -20°C에서 안정적 유지.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human JMJD3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552339 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Covalent modification of histones plays a critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups can be enzymatically removed from histones.
A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes perform this function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate.
Family members include JHDM1 (demethylating histone 3 at lysine 36), JHDM2A, and JMJD2CH3K9 (demethylating histone 3 at lysine 9).
Histone demethylase activity contributes to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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