Thermo Fisher Scientific STMN4 Polyclonal Antibody

Thermo Fisher Scientific STMN4 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

RB3 (Stathmin-4), encoded by the STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins. It possesses a unique N-terminal membrane-associated domain and a stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering.

Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, acting as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 can induce differentiation, suggesting its role during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein among stathmin-related proteins following optic nerve axotomy and may be a critical target in neurodegenerative disease research.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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