Thermo Fisher Scientific GM-CSF Monoclonal Antibody (1089)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

View 9 publications 9 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

1089

Immunogen

Glycosylated, CHO-derived recombinant human GM-CSF

Conjugate

Unconjugated Unconjugated Unconjugated

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• Biotin
• Request custom conjugation

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

RRID

AB_223571

Product Specific Information

M501 targets Human GM-CSF in ELISA applications and shows reactivity with Human samples.

The M501 immunogen is glycosylated, CHO-derived recombinant human GM-CSF.

M501 detects Human GM-CSF which has a predicted molecular weight of approximately 14 kDa.

This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

Target Information

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.