Thermo Fisher Scientific NAGPA Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NAGPA. Recombinant protein control fragment (Product #RP-103542). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NAGPA,uniProtId:Q9UK23-1,ncbiNodeId:9606,antigenRange:140-272,antigenLength:515,antigenImageFileName:PA5-64149_NAGPA_Q9UK23-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64149_NAGPA_Q9UK23-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644442

Product Specific Information

Immunogen sequence: FFRMNSGECL GNVVSDERRV SSSGGLQNAQ FGIRRDGTLV TGYLSEEEVL DTENPFVQLL SGVVWLIRNG SIYINESQAT ECDETQETGS FSKFVNVISA RTAIGHDRKG QLVLFHADGQ TEQRGINLWE MAE

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.

Target Information

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as uncovering enzyme or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.