Thermo Fisher Scientific NAGPA Polyclonal Antibody
Human NAGPA 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS(pH 7.2) 및 40% 글리세롤 함유. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NAGPA. Recombinant protein control fragment (Product #RP-103542) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644442 |
Product Specific Information
Immunogen sequence:
FFRMNSGECL GNVVSDERRV SSSGGLQNAQ FGIRRDGTLV TGYLSEEEVL DTENPFVQLL SGVVWLIRNG SIYINESQAT ECDETQETGS FSKFVNVISA RTAIGHDRKG QLVLFHADGQ TEQRGINLWE MAE
Sequence identity:
- Mouse: 89%
- Rat: 92%
Target Information
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network.
This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases.
Commonly known as uncovering enzyme (UCE), this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties, producing the recognition marker.
The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers.
Mutations in this gene are associated with developmental stuttering in human patients.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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