Thermo Fisher Scientific SCUBE1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 100%

Target Information

SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm, and limb buds.
The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca²⁺-dependent fashion.
In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity.
Genetic ablation of this region resulted in brain malformation in mouse embryos, suggesting SCUBE1 plays a role in brain morphogenesis.
SCUBE1 has also been implicated in early craniofacial development in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 항체의 항원 구조 이미지: PA5-70696_SCUBE1_Q6NZL8-1_Rabbit.svg 및 PA5-70696_SCUBE1_Q6NZL8-1_Rabbit_PDP.jpeg)