Thermo Fisher Scientific IkB zeta Polyclonal Antibody
IkB zeta 단백질을 검출하기 위한 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFKBIZ (Accession Q9BYH8), corresponding to amino acid residues M280–P330 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853642 |
Product Specific Information
Antibody detects endogenous levels of total NFKBIZ.
Target Information
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaB-zeta is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly in T-lymphocytes, fibroblasts, and endothelial cells.
IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65, and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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