Thermo Fisher Scientific IRAK1BP1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

20 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IRAK1BP1 (NP_001010844.1, 1 a.a. approximately 260 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IRAK1BP1,uniProtId:Q5VVH5-1,ncbiNodeId:9606,antigenRange:1-260,antigenLength:260,antigenImageFileName:H00134728-B01P_IRAK1BP1_Q5VVH5-1_House_mouse.svg,antigenImageFileNamePDP:H00134728-B01P_IRAK1BP1_Q5VVH5-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV KGKEKRKKHL

Target Information

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.