Thermo Fisher Scientific ADRA1A Monoclonal Antibody (4C7)
인간 ADRA1A 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 ELISA에 적합합니다. PBS 버퍼 내 액상 형태이며, 보존제 무첨가 상태로 -20°C에서 보관합니다. 혈압 조절 및 세포 신호 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C7 |
| Immunogen | ADRA1A (NP_150646, 1–27 a.a.) 부분 재조합 단백질, GST 태그 포함 (GST 태그 MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MVFLSGNASD SSNCTQPPAP VNISKAI
Target Information
Adrenergic receptors (ARs) belong to the 7-transmembrane domain G-protein-coupled receptor superfamily that bind endogenous catecholamines epinephrine and norepinephrine.
There are nine receptor subtypes identified:
- Alpha-1 ARs: 1A/D, 1B, 1C
- Alpha-2 ARs: 2A, 2B, 2C
- Beta ARs: 1, 2, 3
ARs are involved in disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence.
Alpha-1A adrenergic receptor subtypes regulate blood pressure through vascular tone and cardiac output modulation.
They also influence uterine contraction, hepatic glucose metabolism, HSP70 expression, proto-oncogene expression, and mitogenesis.
Norepinephrine activation of alpha-1 AR can increase nitric oxide synthase (NOS) in the hypothalamus, potentially suppressing luteinizing hormone (LH) and sex hormone release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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