Thermo Fisher Scientific p53 Monoclonal Antibody (OTI5B2), TrueMAB

Applications

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. p53 up-regulation leads to transcription of genes like p21waf1, resulting in G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 also relates to aging, oxidative stress, and cognitive functions such as learning and memory. Normally expressed at low levels, p53 increases in transformed cells and contributes to malignancy. Mutations in p53 disrupt DNA binding and tumor suppressor activity, with TP53 gene alterations observed in both somatic and germline mutations, including Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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