Thermo Fisher Scientific Progranulin Monoclonal Antibody (333731)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (Frozen) (IHC (F))

8-25 µg/mL

-

Product Specifications

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

333731

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Progranulin/PGRN Thr18-Leu589 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Progranulin,uniProtId:P28798-1,ncbiNodeId:10090,antigenRange:18-589,antigenLength:589,antigenImageFileName:MA5-24063_Progranulin_P28798-1_Rat.svg,antigenImageFileNamePDP:MA5-24063_Progranulin_P28798-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2609052

Product Specific Information

In direct ELISAs and Western blots, 100% cross-reactivity with recombinant human Progranulin is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.