Thermo Fisher Scientific IFN beta Monoclonal Antibody (MMHB-3)

Applications

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Neutralization (Neu)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Specificity: Neutralizes human interferon beta. For optimal neutralization of the anti-viral effect of human interferon beta, it is recommended to use sheep polyclonal antibody to human interferon beta (Product #314001).
• Activity: Interferon was titrated using the cytopathic effect inhibition assay, where 1 unit/mL of interferon produced a 50% endpoint. One neutralization unit equals the amount of serum required to neutralize one unit of human IFN beta to a 50% endpoint.
• Purity: >95%
• Endotoxin Level: <1 EU/µg
• Storage: Store at -20°C for short-term (less than 6 months). For long-term storage, aliquot and store at -70°C or below to maintain full activity, avoiding freeze/thaw cycles.
• Packaging: Packaged by and distributed for PBL Assay Science.

Target Information

Type I Interferons (IFN-α/β) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit tumor development. IFN-beta binding activates tyrosine kinases Jak1 and Tyk2, leading to phosphorylation of STAT transcription factors and expression of immune response genes. Members of the toll-like receptor (TLR) family also stimulate IFN-beta production. Clinically, IFN-beta is used for treating tumors, infections, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.