Merck Anti-NEBL antibody produced in rabbit

Anti-NEBL antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies

Affinity isolated antibody, buffered aqueous glycerol solution

Anti-Nebulette / Anti-Actin-binding Z-disk protein

The NEBL (nebulette) gene encodes a nebulin-like protein with a molecular mass of approximately 107 kDa, predominantly expressed in cardiac muscle. This protein shares significant similarity with the C-terminal region of human nebulin, an actin-binding skeletal muscle protein. Both proteins contain:

• Highly related C-terminal repeats
• A serine-rich domain
• An SH3 domain

The NEBL gene is located on human chromosome 10p12.
A short linker domain connects 22 nebulin-like repeats to a C-terminal Src homology 3 (SH3) domain. The repeat domain binds to actin filaments, while the linker domain targets this association to Z-lines and dense bodies. The linker and SH3 domains can differentiate between these structures.

An alternative splice variant, LIM-nebulette, is expressed in non-muscle cells, where it interacts with Zyxin via the SH3 domain, along with Lasp-1, contributing to the organization of focal adhesions.