Merck Anti-FOXO1 Antibody, clone 2H8.2

Anti-FOXO1 Antibody, clone 2H8.2

clone 2H8.2, from mouse

Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, forkhead box O1, forkhead box O1A (rhabdomyosarcoma), forkhead homolog in rhabdomyosarcoma

Quality Level

100

생물학적 소스

mouse

항체 형태

purified antibody

antibody product type

primary antibodies

클론

2H8.2, monoclonal

species reactivity

human, rat, mouse

포장

antibody small pack of 25 μg

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

동형

IgG1κ

NCBI 수납 번호

NP_002006.2

UniProt 수납 번호

Q12778

배송 상태

ambient

Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Gross, D.N., 2009).