Merck Anti-Beclin-1 Antibody, clone 9A1.1

Anti-Beclin-1 Antibody, clone 9A1.1

clone 9A1.1, from mouse

Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197

Quality Level

100

생물학적 소스

mouse

항체 형태

purified immunoglobulin

antibody product type

primary antibodies

클론

9A1.1, monoclonal

species reactivity

human

포장

antibody small pack of 25 μg

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

동형

IgG2aκ

NCBI 수납 번호

NP_003757

UniProt 수납 번호

Q14457

배송 상태

ambient

저장 온도

2-8°C

Gene Information

human ... BECN1(8678)

The Beclin-1 (BECN1) gene encodes a 60 kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity, tumorigenesis, and has been found to ameliorate the neurodegenerative pathology in α-Synuclein models of Parkinson′s and lewy body diseases. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport (3).